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- B37e3922abd2b53a8bcdf20b783300ba7 NCIT_P378 "NCI" @default.
- B37e3922abd2b53a8bcdf20b783300ba7 type Axiom @default.
- B37e3922abd2b53a8bcdf20b783300ba7 annotatedProperty IAO_0000115 @default.
- B37e3922abd2b53a8bcdf20b783300ba7 annotatedSource NCIT_C29648 @default.
- B37e3922abd2b53a8bcdf20b783300ba7 annotatedTarget "Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs with premature stop codons and mark the transcript for rapid decay. Degrading mRNAs from both ends, NMD involves decapping, deadenylating, and exonucleolytic activities." @default.