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- B38344b1e8d0682d1e138bde0a611f6c5 NCIT_P378 "NCI" @default.
- B38344b1e8d0682d1e138bde0a611f6c5 type Axiom @default.
- B38344b1e8d0682d1e138bde0a611f6c5 annotatedProperty IAO_0000115 @default.
- B38344b1e8d0682d1e138bde0a611f6c5 annotatedSource NCIT_C102852 @default.
- B38344b1e8d0682d1e138bde0a611f6c5 annotatedTarget "An orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types." @default.