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- B386823eda686b63c15c71421ad8f9bd7 date_retrieved "2012-09-17" @default.
- B386823eda686b63c15c71421ad8f9bd7 external_class "VHOG:0000049" @default.
- B386823eda686b63c15c71421ad8f9bd7 ontology "VHOG" @default.
- B386823eda686b63c15c71421ad8f9bd7 source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)" @default.
- B386823eda686b63c15c71421ad8f9bd7 source "http://bgee.unil.ch/" @default.
- B386823eda686b63c15c71421ad8f9bd7 type Axiom @default.
- B386823eda686b63c15c71421ad8f9bd7 annotatedProperty UBPROP_0000003 @default.
- B386823eda686b63c15c71421ad8f9bd7 annotatedSource UBERON_0000016 @default.
- B386823eda686b63c15c71421ad8f9bd7 annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" @default.