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- B38abea21b068f07fee38dc7eff56dd54 NCIT_P378 "NCI" @default.
- B38abea21b068f07fee38dc7eff56dd54 type Axiom @default.
- B38abea21b068f07fee38dc7eff56dd54 annotatedProperty IAO_0000115 @default.
- B38abea21b068f07fee38dc7eff56dd54 annotatedSource NCIT_C200128 @default.
- B38abea21b068f07fee38dc7eff56dd54 annotatedTarget "A radioconjugate consisting of an Evans blue (EB) modified fibroblast activation protein inhibitor (FAPi), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecane tetraacetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. Upon administration of lutetium Lu 177 LNC1004, the FAPi moiety targets and binds to FAP-expressing cancer-associated fibroblasts (CAFs). Upon binding and internalization, the radioconjugate specifically delivers a cytotoxic dose of beta radiation to FAP-expressing CAFs. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME)." @default.