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- B38c7bff1796c2c07346b74d1d00d2d61 NCIT_P378 "NCI" @default.
- B38c7bff1796c2c07346b74d1d00d2d61 type Axiom @default.
- B38c7bff1796c2c07346b74d1d00d2d61 annotatedProperty IAO_0000115 @default.
- B38c7bff1796c2c07346b74d1d00d2d61 annotatedSource NCIT_C66133 @default.
- B38c7bff1796c2c07346b74d1d00d2d61 annotatedTarget "The fumarate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion." @default.