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- B3949eab655aac0a1b184b14b8222a585 NCIT_P378 "NCI" @default.
- B3949eab655aac0a1b184b14b8222a585 type Axiom @default.
- B3949eab655aac0a1b184b14b8222a585 annotatedProperty IAO_0000115 @default.
- B3949eab655aac0a1b184b14b8222a585 annotatedSource NCIT_C115977 @default.
- B3949eab655aac0a1b184b14b8222a585 annotatedTarget "An orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival." @default.