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- B39fd0ccf797e4e1868f800b0285591d1 NCIT_P378 "NCI" @default.
- B39fd0ccf797e4e1868f800b0285591d1 type Axiom @default.
- B39fd0ccf797e4e1868f800b0285591d1 annotatedProperty IAO_0000115 @default.
- B39fd0ccf797e4e1868f800b0285591d1 annotatedSource NCIT_C142788 @default.
- B39fd0ccf797e4e1868f800b0285591d1 annotatedTarget "The hydrochloride salt form of ivospemin, an analogue of naturally occurring polyamine (PA), with potential antineoplastic activity. Upon subcutaneous administration, ivospemin displaces endogenous PAs from PA-binding sites on the cell surface, which prevents internalization of PA. This inhibits PA-dependent cell cycle processes and results in cell cycle arrest, the induction of apoptosis, and inhibition of tumor cell proliferation. PA uptake is upregulated in various tumor types and increased levels of PA leads to enhanced tumor cell growth." @default.