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- B3a185da69d985c48bb901999e681eec5 NCIT_P378 "NCI" @default.
- B3a185da69d985c48bb901999e681eec5 type Axiom @default.
- B3a185da69d985c48bb901999e681eec5 annotatedProperty IAO_0000115 @default.
- B3a185da69d985c48bb901999e681eec5 annotatedSource NCIT_C175198 @default.
- B3a185da69d985c48bb901999e681eec5 annotatedTarget "The besylate ester form of remimazolam, a short-acting benzodiazepine derivative that is structurally related to midazolam, with sedative-hypnotic activity. Upon administration, remimazolam targets and binds to a specific site on the gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability." @default.