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- B3a49b0ae92bd664a35ed52f8e0f0faf7 NCIT_P378 "NCI" @default.
- B3a49b0ae92bd664a35ed52f8e0f0faf7 type Axiom @default.
- B3a49b0ae92bd664a35ed52f8e0f0faf7 annotatedProperty IAO_0000115 @default.
- B3a49b0ae92bd664a35ed52f8e0f0faf7 annotatedSource NCIT_C150807 @default.
- B3a49b0ae92bd664a35ed52f8e0f0faf7 annotatedTarget "A controlled-release intravesical system consisting of a small flexible tube-like device with a solid core composed of gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue, with antineoplastic activity. Upon placement of the gemcitabine-releasing intravesical system (GemRIS) into the bladder, gemcitabine is gradually and continuously released from the system over an extended period of time before being removed from the bladder. Upon release, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of apoptosis of bladder tumor cells. In addition, dFdCDP inhibits ribonucleotide reductase (RNR) and reduces the deoxynucleotide pool available for DNA synthesis." @default.