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- B3a5d4ed7007686e11f535ea254eaacd9 NCIT_P378 "NCI" @default.
- B3a5d4ed7007686e11f535ea254eaacd9 type Axiom @default.
- B3a5d4ed7007686e11f535ea254eaacd9 annotatedProperty IAO_0000115 @default.
- B3a5d4ed7007686e11f535ea254eaacd9 annotatedSource NCIT_C63653 @default.
- B3a5d4ed7007686e11f535ea254eaacd9 annotatedTarget "A natural and synthetic xanthophyll and nonprovitamin A carotenoid, with potential antioxidant, anti-inflammatory and antineoplastic activities. Upon administration, astaxanthin may act as an antioxidant and reduce oxidative stress, thereby preventing protein and lipid oxidation and DNA damage. By decreasing the production of reactive oxygen species (ROS) and free radicals, it may also prevent ROS-induced activation of nuclear factor-kappa B (NF-kB) transcription factor and the production of inflammatory cytokines such as interleukin-1beta (IL-1b), IL-6 and tumor necrosis factor-alpha (TNF-a). In addition, astaxanthin may inhibit cyclooxygenase-1 (COX-1) and nitric oxide (NO) activities, thereby reducing inflammation. Oxidative stress and inflammation play key roles in the pathogenesis of many diseases, including cardiovascular, neurological, autoimmune and neoplastic diseases." @default.