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- B3a67e9d99a187807b4e9511dd6f95b63 NCIT_P378 "NCI" @default.
- B3a67e9d99a187807b4e9511dd6f95b63 type Axiom @default.
- B3a67e9d99a187807b4e9511dd6f95b63 annotatedProperty IAO_0000115 @default.
- B3a67e9d99a187807b4e9511dd6f95b63 annotatedSource NCIT_C162533 @default.
- B3a67e9d99a187807b4e9511dd6f95b63 annotatedTarget "A novel small molecule Src family kinase inhibitor with potential antiangiogenic activity. Upon administration, Src kinase inhibitor AP23846 selectively binds to and stabilizes an inactive ATP-binding site conformation leading to reduced Src kinase activity. This may reduce the production of pro-angiogenic factors, vascular endothelial growth factor (VEGF) and interleukin (IL)-8. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis." @default.