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- B3ad69b9d12f385f2e5752ea9aeeb74e8 NCIT_P378 "BIOCARTA" @default.
- B3ad69b9d12f385f2e5752ea9aeeb74e8 type Axiom @default.
- B3ad69b9d12f385f2e5752ea9aeeb74e8 annotatedProperty NCIT_P325 @default.
- B3ad69b9d12f385f2e5752ea9aeeb74e8 annotatedSource NCIT_C39169 @default.
- B3ad69b9d12f385f2e5752ea9aeeb74e8 annotatedTarget "Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. (This definition may be outdated - see the DesignNote.)" @default.