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- B3b61ff4ced84c0c01aa2cac2cf9bb29b NCIT_P378 "NCI" @default.
- B3b61ff4ced84c0c01aa2cac2cf9bb29b type Axiom @default.
- B3b61ff4ced84c0c01aa2cac2cf9bb29b annotatedProperty IAO_0000115 @default.
- B3b61ff4ced84c0c01aa2cac2cf9bb29b annotatedSource NCIT_C65503 @default.
- B3b61ff4ced84c0c01aa2cac2cf9bb29b annotatedTarget "A organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity." @default.