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- B3b6a25e540ee429084bedf51897d3285 NCIT_P378 "NCI" @default.
- B3b6a25e540ee429084bedf51897d3285 type Axiom @default.
- B3b6a25e540ee429084bedf51897d3285 annotatedProperty IAO_0000115 @default.
- B3b6a25e540ee429084bedf51897d3285 annotatedSource NCIT_C180622 @default.
- B3b6a25e540ee429084bedf51897d3285 annotatedTarget "The mesylate salt form of temuterkib, an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, temuterkib inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.