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- B3b6c88c4246edda04914cf8081c22b68 NCIT_P378 "NCI" @default.
- B3b6c88c4246edda04914cf8081c22b68 type Axiom @default.
- B3b6c88c4246edda04914cf8081c22b68 annotatedProperty IAO_0000115 @default.
- B3b6c88c4246edda04914cf8081c22b68 annotatedSource NCIT_C61882 @default.
- B3b6c88c4246edda04914cf8081c22b68 annotatedTarget "The sulfate salt form of penbutolol, a lipophilic, nonselective beta-adrenergic receptor antagonist with anti-anginal and antihypertensive activities. Penbutolol competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels." @default.