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- B3b74db806c313dd2d39fccd8b126f2e4 NCIT_P378 "NCI" @default.
- B3b74db806c313dd2d39fccd8b126f2e4 type Axiom @default.
- B3b74db806c313dd2d39fccd8b126f2e4 annotatedProperty IAO_0000115 @default.
- B3b74db806c313dd2d39fccd8b126f2e4 annotatedSource NCIT_C2225 @default.
- B3b74db806c313dd2d39fccd8b126f2e4 annotatedTarget "A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)" @default.