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- B3b97d89e5cfc42d39e1a7a2f9d55834c NCIT_P378 "NCI" @default.
- B3b97d89e5cfc42d39e1a7a2f9d55834c type Axiom @default.
- B3b97d89e5cfc42d39e1a7a2f9d55834c annotatedProperty IAO_0000115 @default.
- B3b97d89e5cfc42d39e1a7a2f9d55834c annotatedSource NCIT_C91089 @default.
- B3b97d89e5cfc42d39e1a7a2f9d55834c annotatedTarget "An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Dysregulated activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo." @default.