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- B3c7e79cceb4c32b26768d67303d4d0bc NCIT_P378 "NCI" @default.
- B3c7e79cceb4c32b26768d67303d4d0bc type Axiom @default.
- B3c7e79cceb4c32b26768d67303d4d0bc annotatedProperty IAO_0000115 @default.
- B3c7e79cceb4c32b26768d67303d4d0bc annotatedSource NCIT_C83581 @default.
- B3c7e79cceb4c32b26768d67303d4d0bc annotatedTarget "A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor cell proliferation. Glutathione S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies." @default.