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- B3cb79e9da9c912eb9265de6d7bc88da4 NCIT_P378 "NCI" @default.
- B3cb79e9da9c912eb9265de6d7bc88da4 type Axiom @default.
- B3cb79e9da9c912eb9265de6d7bc88da4 annotatedProperty IAO_0000115 @default.
- B3cb79e9da9c912eb9265de6d7bc88da4 annotatedSource NCIT_C2472 @default.
- B3cb79e9da9c912eb9265de6d7bc88da4 annotatedTarget "A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis." @default.