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- B3cd9a6ede5f1d3fa6cc176882d364be4 NCIT_P378 "NCI" @default.
- B3cd9a6ede5f1d3fa6cc176882d364be4 type Axiom @default.
- B3cd9a6ede5f1d3fa6cc176882d364be4 annotatedProperty IAO_0000115 @default.
- B3cd9a6ede5f1d3fa6cc176882d364be4 annotatedSource NCIT_C47650 @default.
- B3cd9a6ede5f1d3fa6cc176882d364be4 annotatedTarget "The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB)." @default.