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- B3d068c8285b49e683cb6dbd303a634c1 NCIT_P378 "NCI" @default.
- B3d068c8285b49e683cb6dbd303a634c1 type Axiom @default.
- B3d068c8285b49e683cb6dbd303a634c1 annotatedProperty IAO_0000115 @default.
- B3d068c8285b49e683cb6dbd303a634c1 annotatedSource NCIT_C179617 @default.
- B3d068c8285b49e683cb6dbd303a634c1 annotatedTarget "A depot formulation containing the decanoate ester of abiraterone, a steroidal compound with antiandrogen activity. Upon administration, abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. This suppresses testosterone production by both the testes and the adrenals to castrate-range levels. This may decrease androgen-dependent growth signaling and inhibit the proliferation of androgen-dependent tumor cells." @default.