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- B3d2a4a7677854e25e56e8c20bd8efcf6 NCIT_P378 "KEGG" @default.
- B3d2a4a7677854e25e56e8c20bd8efcf6 type Axiom @default.
- B3d2a4a7677854e25e56e8c20bd8efcf6 annotatedProperty NCIT_P325 @default.
- B3d2a4a7677854e25e56e8c20bd8efcf6 annotatedSource NCIT_C91490 @default.
- B3d2a4a7677854e25e56e8c20bd8efcf6 annotatedTarget "Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process." @default.