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- B3daa383c1ff812a55ba4bd4f34bd1bbe NCIT_P378 "NCI" @default.
- B3daa383c1ff812a55ba4bd4f34bd1bbe type Axiom @default.
- B3daa383c1ff812a55ba4bd4f34bd1bbe annotatedProperty IAO_0000115 @default.
- B3daa383c1ff812a55ba4bd4f34bd1bbe annotatedSource NCIT_C121539 @default.
- B3daa383c1ff812a55ba4bd4f34bd1bbe annotatedTarget "A nanoparticle-based formulation containing the poorly water-soluble, second-generation taxane analog docetaxel, with antineoplastic activity. Upon intravenous administration of the docetaxel-loaded nanopharmaceutical CRLX301, the nanoparticles are able to accumulate at the tumor site due to the unique characteristics of the tumor's vasculature, while avoiding normal, healthy tissue. In turn, CRLX301 is taken up by the tumor cell via macropinocytosis. Subsequently, docetaxel is slowly released into the cytoplasm where it binds to and stabilizes the beta-subunit of tubulin, thereby stabilizing microtubules and inhibiting microtubule disassembly. This prevents mitosis and results in cell death. Compared to the administration of docetaxel alone, this formulation is able to increase docetaxel's efficacy while avoiding systemic exposure, which minimizes its toxicity." @default.