Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B3ee9cc6cf0d53a8084d66cbe8d89683c> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B3ee9cc6cf0d53a8084d66cbe8d89683c NCIT_P378 "NCI" @default.
- B3ee9cc6cf0d53a8084d66cbe8d89683c type Axiom @default.
- B3ee9cc6cf0d53a8084d66cbe8d89683c annotatedProperty IAO_0000115 @default.
- B3ee9cc6cf0d53a8084d66cbe8d89683c annotatedSource NCIT_C61625 @default.
- B3ee9cc6cf0d53a8084d66cbe8d89683c annotatedTarget "A second generation bisphosphonate and synthetic analog of pyrophosphate with anti-bone-resorption activity. Alendronic acid binds to and inhibits the activity of farnesyl pyrophosphate synthetase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. As a result, bone resorption and turnover are reduced." @default.