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- B4007c95eeb85319bcf9e62003f8b7bf4 NCIT_P378 "NCI" @default.
- B4007c95eeb85319bcf9e62003f8b7bf4 type Axiom @default.
- B4007c95eeb85319bcf9e62003f8b7bf4 annotatedProperty IAO_0000115 @default.
- B4007c95eeb85319bcf9e62003f8b7bf4 annotatedSource NCIT_C178139 @default.
- B4007c95eeb85319bcf9e62003f8b7bf4 annotatedTarget "A vaccine composed of a molecular clamp stabilized form of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein (SP) combined with a squalene-based vaccine adjuvant, MF59, with potential immunomodulating and anti-COVID-19 activities. Upon administration of MF59 adjuvanted molecular clamp stabilized SARS-CoV-2 SP vaccine, the SARS-CoV-2 SP activates the immune system to produce anti-SARS-CoV-2 SP antibodies and T-cell responses against SARS-CoV-2 SP. The antibodies recognize the SP and kill SARS-CoV-2. This prevents SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. The molecular clamp holds the SARS-CoV-2 SP in the otherwise unstable prefusion position, which may generate a more robust antibody response. The adjuvant strongly stimulates both T-cell and antibody immune responses when combined with the molecular clamp stabilized SARS-CoV-2 SP." @default.