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- B40b76170ec3ab938d320818a1990c488 NCIT_P378 "NCI" @default.
- B40b76170ec3ab938d320818a1990c488 type Axiom @default.
- B40b76170ec3ab938d320818a1990c488 annotatedProperty IAO_0000115 @default.
- B40b76170ec3ab938d320818a1990c488 annotatedSource NCIT_C163976 @default.
- B40b76170ec3ab938d320818a1990c488 annotatedTarget "An immunoglobulin G4 (IgG4) bispecific antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, voxalatamab simultaneously binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA, a tumor associated antigen, is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.