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- B40f07c3a2fd065d49b3492e4b117a405 NCIT_P378 "NCI" @default.
- B40f07c3a2fd065d49b3492e4b117a405 type Axiom @default.
- B40f07c3a2fd065d49b3492e4b117a405 annotatedProperty IAO_0000115 @default.
- B40f07c3a2fd065d49b3492e4b117a405 annotatedSource NCIT_C73835 @default.
- B40f07c3a2fd065d49b3492e4b117a405 annotatedTarget "The pamoate salt form of a semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis." @default.