Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B41270fffc9d09d09f50ff3149f7a2233> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B41270fffc9d09d09f50ff3149f7a2233 NCIT_P378 "NCI" @default.
- B41270fffc9d09d09f50ff3149f7a2233 type Axiom @default.
- B41270fffc9d09d09f50ff3149f7a2233 annotatedProperty comment @default.
- B41270fffc9d09d09f50ff3149f7a2233 annotatedSource NCIT_C19331 @default.
- B41270fffc9d09d09f50ff3149f7a2233 annotatedTarget "The three conserved (GPCR Family) widely expressed types of Adenosine Receptors (A1, A2, A3) exhibit specific patterns of ligand binding and unique tissue distributions. Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition. Regulating diverse physiologic functions (cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation), adenosine receptors modulate the activity of neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress." @default.