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- B414d58433e06ff03ebd45ed812dea59e NCIT_P378 "NCI" @default.
- B414d58433e06ff03ebd45ed812dea59e type Axiom @default.
- B414d58433e06ff03ebd45ed812dea59e annotatedProperty IAO_0000115 @default.
- B414d58433e06ff03ebd45ed812dea59e annotatedSource NCIT_C150382 @default.
- B414d58433e06ff03ebd45ed812dea59e annotatedTarget "A preparation of autologous T-lymphocytes ex vivo transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN18.2CAR-transduced T lymphocytes specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.