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- B41572aa0fbf53dc68c94cb4aacf79609 NCIT_P378 "NCI" @default.
- B41572aa0fbf53dc68c94cb4aacf79609 type Axiom @default.
- B41572aa0fbf53dc68c94cb4aacf79609 annotatedProperty IAO_0000115 @default.
- B41572aa0fbf53dc68c94cb4aacf79609 annotatedSource NCIT_C72139 @default.
- B41572aa0fbf53dc68c94cb4aacf79609 annotatedTarget "An orally available, synthetic benzenoid that acts as an agonist for the mu-opioid receptor (MOR) and inhibits the reuptake of noradrenaline, with potential anti-nociceptive activity. Upon oral administration, tapentadol binds to the MOR which enhances MOR-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. Tapentadol also inhibits the reuptake of noradrenaline, which increases the levels of noradrenaline (NA), activates the inhibitory alpha-2 receptors and results in an analgesic effect." @default.