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- B415cab7eb759005e09775e09f75bdfd1 NCIT_P378 "NCI" @default.
- B415cab7eb759005e09775e09f75bdfd1 type Axiom @default.
- B415cab7eb759005e09775e09f75bdfd1 annotatedProperty IAO_0000115 @default.
- B415cab7eb759005e09775e09f75bdfd1 annotatedSource NCIT_C1379 @default.
- B415cab7eb759005e09775e09f75bdfd1 annotatedTarget "A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)" @default.