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- B4161df4284a25f3365478f8eda60cf90 NCIT_P378 "NCI" @default.
- B4161df4284a25f3365478f8eda60cf90 type Axiom @default.
- B4161df4284a25f3365478f8eda60cf90 annotatedProperty IAO_0000115 @default.
- B4161df4284a25f3365478f8eda60cf90 annotatedSource NCIT_C91072 @default.
- B4161df4284a25f3365478f8eda60cf90 annotatedTarget "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.