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- B4186418cdcc3a3f40d6ee20dd5e37b8a NCIT_P378 "NCI" @default.
- B4186418cdcc3a3f40d6ee20dd5e37b8a type Axiom @default.
- B4186418cdcc3a3f40d6ee20dd5e37b8a annotatedProperty IAO_0000115 @default.
- B4186418cdcc3a3f40d6ee20dd5e37b8a annotatedSource NCIT_C199626 @default.
- B4186418cdcc3a3f40d6ee20dd5e37b8a annotatedTarget "A fusion protein composed of MDK-1472, a structurally unrelated engineered mimetic peptide of endogenous human cytokine interleukin-7 (hIL-7), fused to an immunoglobulin G2 (IgG2) Fc-domain, with hematopoietic and immunopotentiating activities. Upon administration, Fc fusion IL-7 mimetic MDK-703 mimics endogenous cytokine IL-7 and binds to the IL-7 receptor (IL7R) on immune cells. The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which leads to the expansion of various subsets of T-lymphocytes, including memory T-cells, especially CD8 and CD4 stem cell memory T-cells (Tscm), central memory T-cells (Tcm) and effector memory T-cells (Tem). This may improve immune recovery and activation and may enhance T-cell-mediated anti-tumor immune responses. Fusion to the Fc domain enhances the half-life of the IL-7 mimetic. As MDK-703 is unrelated in sequence to the natural cytokine, it is unlikely to generate anti-drug antibodies (ADAs) that neutralize the endogenous IL-7 cytokine. IL-7 is a cytokine critical for the development, maintenance and survival of T-cell subpopulations." @default.