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- B426f2b7a3046c4fdad8dfd1aa2834dba NCIT_P378 "NCI" @default.
- B426f2b7a3046c4fdad8dfd1aa2834dba type Axiom @default.
- B426f2b7a3046c4fdad8dfd1aa2834dba annotatedProperty IAO_0000115 @default.
- B426f2b7a3046c4fdad8dfd1aa2834dba annotatedSource NCIT_C133072 @default.
- B426f2b7a3046c4fdad8dfd1aa2834dba annotatedTarget "A preparation of genetically modified central memory (Tcm) enriched T-cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity." @default.