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- B42a5da1cfea86bb0a8bb96dfd3b99d9b NCIT_P378 "NCI" @default.
- B42a5da1cfea86bb0a8bb96dfd3b99d9b type Axiom @default.
- B42a5da1cfea86bb0a8bb96dfd3b99d9b annotatedProperty IAO_0000115 @default.
- B42a5da1cfea86bb0a8bb96dfd3b99d9b annotatedSource NCIT_C192177 @default.
- B42a5da1cfea86bb0a8bb96dfd3b99d9b annotatedTarget "The mesylate salt form of purinostat, an inhibitor of histone deacetylase (HDAC) classes I and IIb, with potential antineoplastic activities. Upon administration, purinostat selectively inhibits the catalytic activity of class I and IIb HDACs, which results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibits tumor cell division and induces tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Class I HDACs are located in the nucleus and include HDACs 1, 2, 3, and 8; class IIb HDACs include HDAC 6 and 10 and are located in both the nucleus and the cytoplasm." @default.