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- B42ae76a27a0befefae32cce2fea42980 NCIT_P378 "BIOCARTA" @default.
- B42ae76a27a0befefae32cce2fea42980 type Axiom @default.
- B42ae76a27a0befefae32cce2fea42980 annotatedProperty NCIT_P325 @default.
- B42ae76a27a0befefae32cce2fea42980 annotatedSource NCIT_C39178 @default.
- B42ae76a27a0befefae32cce2fea42980 annotatedTarget "p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (This definition may be outdated - see the DesignNote.)" @default.