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- B42bc8568068cabf043889d1f465009ed NCIT_P378 "NCI" @default.
- B42bc8568068cabf043889d1f465009ed type Axiom @default.
- B42bc8568068cabf043889d1f465009ed annotatedProperty IAO_0000115 @default.
- B42bc8568068cabf043889d1f465009ed annotatedSource NCIT_C870 @default.
- B42bc8568068cabf043889d1f465009ed annotatedTarget "A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis." @default.