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- B42cd513c977ea9c1d10d1716b4d975d0 NCIT_P378 "NCI" @default.
- B42cd513c977ea9c1d10d1716b4d975d0 type Axiom @default.
- B42cd513c977ea9c1d10d1716b4d975d0 annotatedProperty IAO_0000115 @default.
- B42cd513c977ea9c1d10d1716b4d975d0 annotatedSource NCIT_C152666 @default.
- B42cd513c977ea9c1d10d1716b4d975d0 annotatedTarget "The hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis." @default.