Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B42ddcc84b93cd31ca5fb52cc02a62015> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B42ddcc84b93cd31ca5fb52cc02a62015 NCIT_P378 "NCI" @default.
- B42ddcc84b93cd31ca5fb52cc02a62015 type Axiom @default.
- B42ddcc84b93cd31ca5fb52cc02a62015 annotatedProperty IAO_0000115 @default.
- B42ddcc84b93cd31ca5fb52cc02a62015 annotatedSource NCIT_C124229 @default.
- B42ddcc84b93cd31ca5fb52cc02a62015 annotatedTarget "A bifunctional fusion protein composed of an anti-programmed death ligand 1 (PD-L1) human monoclonal antibody, bound to the soluble extracellular domain of human transforming growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities. Upon administration, bintrafusp alfa binds to and neutralizes activated TGFbeta and binds to PD-L1. This prevents TGFbeta- and PD-L1-mediated signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis." @default.