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- B4308223db57c252c998a7a370977d603 NCIT_P378 "NCI" @default.
- B4308223db57c252c998a7a370977d603 type Axiom @default.
- B4308223db57c252c998a7a370977d603 annotatedProperty IAO_0000115 @default.
- B4308223db57c252c998a7a370977d603 annotatedSource NCIT_C84068 @default.
- B4308223db57c252c998a7a370977d603 annotatedTarget "A semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis." @default.