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- B4364e59e71be5e7ed3e3f95e70aa4e52 NCIT_P378 "NCI" @default.
- B4364e59e71be5e7ed3e3f95e70aa4e52 type Axiom @default.
- B4364e59e71be5e7ed3e3f95e70aa4e52 annotatedProperty IAO_0000115 @default.
- B4364e59e71be5e7ed3e3f95e70aa4e52 annotatedSource NCIT_C28820 @default.
- B4364e59e71be5e7ed3e3f95e70aa4e52 annotatedTarget "The besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump." @default.