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- B4417f2eb69face1a0aa9e2fa7163df3c NCIT_P378 "NCI" @default.
- B4417f2eb69face1a0aa9e2fa7163df3c type Axiom @default.
- B4417f2eb69face1a0aa9e2fa7163df3c annotatedProperty IAO_0000115 @default.
- B4417f2eb69face1a0aa9e2fa7163df3c annotatedSource NCIT_C61845 @default.
- B4417f2eb69face1a0aa9e2fa7163df3c annotatedTarget "A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion." @default.