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- B4433a6aaa3916990a735d4471edfd54c NCIT_P378 "NCI" @default.
- B4433a6aaa3916990a735d4471edfd54c type Axiom @default.
- B4433a6aaa3916990a735d4471edfd54c annotatedProperty IAO_0000115 @default.
- B4433a6aaa3916990a735d4471edfd54c annotatedSource NCIT_C965 @default.
- B4433a6aaa3916990a735d4471edfd54c annotatedTarget "An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. (NCI04)" @default.