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- B4496b69248e8efaf53eabde2b17b447d NCIT_P378 "NCI" @default.
- B4496b69248e8efaf53eabde2b17b447d type Axiom @default.
- B4496b69248e8efaf53eabde2b17b447d annotatedProperty IAO_0000115 @default.
- B4496b69248e8efaf53eabde2b17b447d annotatedSource NCIT_C73835 @default.
- B4496b69248e8efaf53eabde2b17b447d annotatedTarget "The pamoate salt form of a semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis." @default.