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- B4576078501381e8cf84ae9c9d639e6b1 NCIT_P378 "NCI" @default.
- B4576078501381e8cf84ae9c9d639e6b1 type Axiom @default.
- B4576078501381e8cf84ae9c9d639e6b1 annotatedProperty IAO_0000115 @default.
- B4576078501381e8cf84ae9c9d639e6b1 annotatedSource NCIT_C2516 @default.
- B4576078501381e8cf84ae9c9d639e6b1 annotatedTarget "An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction." @default.