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- B45fbb62e871f11e423a52b29f1207b30 NCIT_P378 "NCI" @default.
- B45fbb62e871f11e423a52b29f1207b30 type Axiom @default.
- B45fbb62e871f11e423a52b29f1207b30 annotatedProperty IAO_0000115 @default.
- B45fbb62e871f11e423a52b29f1207b30 annotatedSource NCIT_C29103 @default.
- B45fbb62e871f11e423a52b29f1207b30 annotatedTarget "A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic." @default.