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- B460c3070815c48645deb3fa620de3223 NCIT_P378 "NCI" @default.
- B460c3070815c48645deb3fa620de3223 type Axiom @default.
- B460c3070815c48645deb3fa620de3223 annotatedProperty IAO_0000115 @default.
- B460c3070815c48645deb3fa620de3223 annotatedSource NCIT_C1193 @default.
- B460c3070815c48645deb3fa620de3223 annotatedTarget "The trisodium salt of a synthetic organic analogue of inorganic pyrophosphate with antiviral activity. Foscarnet selectively blocks the pyrophosphate binding site of herpesvirus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. This agent does not require phosphorylation by thymidine kinase (TK) or other kinases and therefore is active in vitro against herpes simplex virus (HSV) TK deficient mutants and cytomegalovirus (CMV) UL97 mutants. Because foscarnet crosses the blood brain barrier, it may be used in the treatment of viral infections of the CNS." @default.