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- B4692eb1ddc34090563dce7ccd942b7ad NCIT_P378 "NCI" @default.
- B4692eb1ddc34090563dce7ccd942b7ad type Axiom @default.
- B4692eb1ddc34090563dce7ccd942b7ad annotatedProperty IAO_0000115 @default.
- B4692eb1ddc34090563dce7ccd942b7ad annotatedSource NCIT_C47479 @default.
- B4692eb1ddc34090563dce7ccd942b7ad annotatedTarget "An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord." @default.