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- B46e78119edc8bc48bddcaf9405b2eb76 date_retrieved "2012-09-17" @default.
- B46e78119edc8bc48bddcaf9405b2eb76 external_class "VHOG:0000048" @default.
- B46e78119edc8bc48bddcaf9405b2eb76 ontology "VHOG" @default.
- B46e78119edc8bc48bddcaf9405b2eb76 source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)" @default.
- B46e78119edc8bc48bddcaf9405b2eb76 source "http://bgee.unil.ch/" @default.
- B46e78119edc8bc48bddcaf9405b2eb76 type Axiom @default.
- B46e78119edc8bc48bddcaf9405b2eb76 annotatedProperty UBPROP_0000003 @default.
- B46e78119edc8bc48bddcaf9405b2eb76 annotatedSource UBERON_0000017 @default.
- B46e78119edc8bc48bddcaf9405b2eb76 annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" @default.