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- B47cf86943d2515401dd7173546c0ebdc NCIT_P378 "NCI" @default.
- B47cf86943d2515401dd7173546c0ebdc type Axiom @default.
- B47cf86943d2515401dd7173546c0ebdc annotatedProperty IAO_0000115 @default.
- B47cf86943d2515401dd7173546c0ebdc annotatedSource NCIT_C65308 @default.
- B47cf86943d2515401dd7173546c0ebdc annotatedTarget "A synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent." @default.